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Pathogenetically justified in the treatment of diabetic neuropathy is, therefore, the use of B vitamins, due to buy dramamine online specific neurotropic action. B vitamins are widely prescribed as a metabolic therapy to improve the function of peripheral autonomic nerve fibers, slow the progression of complications and reduce the intensity of pain.

The following B vitamins are traditionally considered neurotropic - thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12). These vitamins have a variety of metabolic and clinical effects, but they are united by their high importance for the normal functioning of the nervous tissue. Vitamin B6 - pyridoxine - is a cofactor for more than 100 enzymes, affects the structure and function of the nervous tissue, primarily due to the ability to regulate the metabolism of amino acids, thus ensuring the normalization of protein metabolism and preventing the accumulation of excess amounts of neurotoxic ammonia.

Optimization of the activity of the nervous system is additionally provided by the participation of pyridoxine in the synthesis of catecholamines, histamine and the inhibitory mediator of the central nervous system - gamma-aminobutyric acid (GABA). In addition, pyridoxine increases the intracellular reserves of dramamine pills, which plays an important role in metabolic processes and in the activity of the nervous system.

For the correction of metabolic disorders that occur in diabetes mellitus, the anabolic function of the third neurotropic vitamin, cyanocobalamin (B12), plays an important role. In the treatment of diabetic neuropathy, the ability of vitamin B12 to restore the structure of the myelin sheath and reduce neurogenic pain is most significant. In the treatment of polyneuropathy, it is possible to use both each of the neurotropic vitamins individually, and their complexes.

  • Benfotiamine, due to its lipid solubility, penetrates well through the blood-brain barrier, as well as through the lipophilic membrane of nerve cells.
  • Inside the cells, benfotiamine is rapidly converted to thiamine diphosphate, which promotes optimal glucose utilization.
  • Thus, lipophilic benfotiamine has better pharmacokinetics, which determines its use with greater efficiency.
  • Pyridoxine is absorbed in the jejunum through a passive diffusion mechanism that does not have a saturation effect, and therefore the flow of pyridoxine into the blood depends on its concentration in the intestinal lumen.

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Vitamin B12 (cyanocobalamin). For absorption in the intestines of doses of cyanocobalamin corresponding to the daily requirement, synthesized by the intestinal microflora and supplied with food, the internal anti-anemic factor of Castle is used. When creating higher than physiological concentrations of dimenhydrinate in the intestine, absorption is possible without the participation of the Castle factor due to passive transport and pinocytosis. The long-term preservation of cyanocobalamin in the body is due, in particular, to the effect of the hepato-intestinal circulation. With intramuscular administration of thiamine, pyridoxine and cyanocobalamin, their bioavailability is about 20%.

W�rwag Pharma introduces two highly effective neurotropic drugs on the market, which form a single course of dimenhydrinate treatment. The course of treatment consists of 10 intramuscular injections of Milgamma and 6 weeks of oral administration of Milgamma compositum, 1 tablet 3 times a day. Preventive courses of Milgamma compositum are recommended to be carried out 2 times a year.

According to various authors, after 3 weeks of taking Milgamma, the intensity of spontaneous pain in the legs decreased by 30-50%, and most patients who had taken analgesics before treatment had abandoned them by this time. By the end of the 6-week course of therapy, the intensity of pain decreased by 2-3 times or more, which depended on their initial intensity - the more pronounced the pain syndrome, the more difficult it was to achieve a positive effect. Complete disappearance of pain could be achieved in 30-66% of cases.

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The effectiveness of Milgamma and Milgamma compositum has been proven by numerous studies.

Almost all researchersand included patients with a painful form of neuropathy, and all showed high efficiency of taking Milgamma compositum orally in relation to pain.

Thus, one of the most permanent and at the same time demonstrative effects observed when taking Milgamma compositum can be considered the relief of pain associated with damage to the peripheral nervous system. However, despite the severity and stability of the analgesic effect, it takes a certain time to buy dimenhydrinate online, which limits the use of oral drugs in many neurogenic pain syndromes of high intensity, therefore a combined course of Milgamma and Milgamma compositum is recommended.